发明名称 |
1-Indolylalkyl-4-(substituierte Pyridinyl)-Piperazine. |
摘要 |
A compound of Formula I and the pharmaceutically acceptable acid addition salts thereof, <CHEM> wherein R<1> and R<2> are independently selected from lower, meaning C1-4, alkyl or hydrogen; R<3>, R<4>, R<8> and R<9> are independently selected from hydrogen, lower alkyl, lower alkoxy, carbamide, halogen, trifluoromethyl and thio-lower alkyl, with the proviso that R<8> and R<9> cannot both be hydrogen at the same time; A is a C5-7 cycloalkanyl or cycloalkenyl ring, or A is <CHEM> wherein n is an integer from 1 to 3 and R<5> is the same as R<1>; and R<6> and R<7> are independently selected from hydrogen, methyl or R<6> and R<7> can be taken together as a methylene bridge, useful as antidepressants. |
申请公布号 |
DE68920482(D1) |
申请公布日期 |
1995.02.23 |
申请号 |
DE1989620482 |
申请日期 |
1989.06.09 |
申请人 |
BRISTOL-MYERS SQUIBB CO., NEW YORK, N.Y., US |
发明人 |
SMITH, DAVID WILLIAM, CLINTON CONNECTICUT 06413, US;YOCCA, FRANK D., MADISON CONNECTICUT 06443, US;YEVICH, JOSEPH PAUL, SOUTHINGTON CONNECTICUT 06489, US;MATTSON, RONALD JOHN, MERIDEN CONNECTICUT 06450, US |
分类号 |
C07D487/04;A61K31/44;A61K31/495;A61P25/24;A61P25/26;C07D401/12;C07D401/14;C07D487/08 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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