ERECTION-INDUCING METHODS AND COMPOSITIONS

摘要

Methods and compositions for inducing penile erections, sufficient for vaginal penetration, in a human male suffering from impotence are provided. Kits containing the compositions in containers for single dosage administration are provided. Compositions for treating impotence that is of psychogenic or neurogenic origin contain a neuropeptide selected from the group consisting vasoactive intestinal peptide (VIP) and peptide N-terminal histidine C-terminal methionineamide (PHM) and are formulated in a pharmaceutically acceptable carrier that has a pH of about 2 to about 4.5, preferably between about 2 and about 3.5, and most preferably about 3. Compositions for treating impotence of almost origin, including severe atherosclerosis, contain (1) a neuropeptide selected from the group consisting of vasoactive intestinal peptide and peptide N-terminal histidine C-terminal methionineamide and (2) an alphaadrenergic blocker, such as phentolamine or prazosin. Ethylenediaminetetraacetic acid (EDTA) can be, and preferably is, included in the formulations to provide stable, physiologically acceptable compositions. Such EDTA-containing compositions are especially suitable for use in kits since, under proper storage conditions, they are stable for prolonged period of time. In practising the method, the composition is administered by intracavernosal injection accompanied by or followed by sexual stimulation.