GLUCOAMYLASE PROMOTER OBTAINED FROM NEUROSPORA CRASSA AND ITS USE IN THE PRODUCTION OF HETEROLOGOUS POLYPEPTIDES

摘要

The invention relates to a method and recombinant means for engineering the production of heterologous peptides in filamentous fungus. The invention involves the genetic manipulation of the glucoamylase gene in order to provide a restriction site in same so that the promoter sequence of said gene can be coupled to a heterologous peptide whereby the production of said peptide will be under the control of the promoter sequence of the glucoamylase gene.