HEPARIN-SELECTIVE POLYMERIC MEMBRANE

摘要

An anion exchange membrane (15) for ionic macromolecules, specifically heparin, which is formed of a polymeric matrix material and an anion exchange material suitable for heparin detection can be employed in an electrochemical sensor arrangement to directly measure the concentration of heparin ions in blood or blood fluid. Potentiometric response to heparin has been observed with membranes comprising 30-70 wt. % polymeric matrix material, such as polyvinyl chloride, 0.1-12 wt. % quaternary ammonium salt, such as tridodecyl methyl ammonium chloride (TDMAC), and 30-70 wt. % of a plasticizer, such as dioctyl sebacate. A solid state sensor (200) employs TDMAC dissolved in a polymeric compound, such as silicone rubber, to form a membrane (270) which is responsive to heparin concentration.