发明名称 |
CLASS I MHC MODULATION OF SURFACE RECEPTOR ACTIVITY |
摘要 |
Methods and compositions are provided for regulating surface membrane receptor responses by modulating interaction between MHC Class I antigen and the surface membrane receptor. Various techniques may be employed for enhancing or reducing the interaction between the MHC Class I antigen and surface membrane receptor (e.g., enhancing surface expression of the MHC Class I antigen or employing agents which affect interaction between MHC Class I antigen and surface receptors). The aggregative characteristics of oligopeptides which act as agents in affecting interaction between MHC Class I antigen and surface receptors may be employed in a screening assay for determining drugs which affect interaction between Class I antigen and surface receptors. Active peptide aggregative characteristics may also be employed in a method of administration of effectors of surface receptor response modulation.
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申请公布号 |
WO9505189(A1) |
申请公布日期 |
1995.02.23 |
申请号 |
WO1994US09189 |
申请日期 |
1994.08.12 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
OLSSON, LENNART;GOODENOW, ROBERT, S.;GOLDSTEIN, AVRAM |
分类号 |
G01N33/566;A61K38/00;A61P43/00;C07K14/485;C07K14/49;C07K14/65;C07K14/705;C07K14/72;C07K14/74;C07K14/79;C07K16/28;(IPC1-7):A61K38/00;A61K45/00 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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