PHARMACEUTICAL PREPARATION AND A PROCESS FOR MAKING SAME

摘要

The invention provides for both a pharmaceutical preparation and a method for inhibiting in vivo the reverse transcriptase enzyme and the replication of human immunodefiency virus (HIV). In one embodiment the pharmaceutical preparation is a complex of dextran, modified dextran, dextran sulphate or polysaccharides and 3'-azido-2',3'-dideoxythymidine (AZT) which may be administered via different routes in appropriate dosage forms, dosage quantities and dosage regimens to patients suffering from a viral disease such as AIDS and its related disorders. This complex represents a novel structure which functions as a structural unit which combines the known additive and synergistic properties of dextran or dextran sulphate with AZT and at the same time appears to ameliorate the toxic effects of AZT.