| 摘要 |
Compounds of formula (I) wherein R1 and R2 are independently H, methyl, halo, carboxy, esterified carboxy, amidated carboxy, carboxymethyl, esterified carboxymethyl or amidated carboxymethyl; R3 and R4 (or each R3 and R4 gnoup, when m or n is 2 or more) are independently selected from halo, amino, nitro, cyano, sulphamoyl, sulphonyl, trifluoromethyl, C1 to C3 alkyl, C1 to C3 alkoxy, hydroxy, C1 to C3 hydroxyalkyl ,C1 to C3 alkylcarboxyamino, carboxy, esterified carboxy and amidated carboxy; R5 and R6 are independently selected from H and the groups recited above for R3; m is from 0 to 4, provided that m is not more than 2 unless R3 is exclusively halo; n is from 0 to 4, provided that n is not more than 2 unless R4 is exclusively halo; R7, R9 and R10 are independently H or C1 to C3 alkyl; R3 is H or C1 to C15 hydrocarbyl, in which one or more hydrogen atoms of the hydrocarbyl group may be replaced by a halogen atom, and up to two of the carbon atoms may be replaced by a nitrogen, oxygen or sulphur atom, provided that R3 does not contain a -O-O-group; U is aryl, substituted aryl, heterocyclic, substituted heterocyclic or cycloalkyl, and Z is a group of formula (II) or (m) (wherein R is H or C1 to C3 alkyl; X is -CO2H or tetrazolyl; Y is H, -CO2H, tetrazolyl, -CH2OH, -CO2Me or -CONH2, and a is from 0 to 2); and pharmaceutically acceptable salts thereof have a high affinity for CCK and/or gastrin receptors.
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