| 摘要 |
<p>The invention provides glycoconjugates which bind polynucleotides in a sequence-selective manner and/or preferentially displace or inhibit binding of transcription factors to their recognition sites on DNA. The DNA-binding glycoconjugates of the invention, exemplified by calicheamicin-MG (as shown in the figure), are used as selective transcriptional antagonists, among other uses.</p> |
