Pharmaceutical composition containing a specific inhibitor of the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase
摘要
A method and a pharmaceutical composition for killing mammalian tumour cells is disclosed and entails cells being exposed to light in the presence of a photoactivatable tetrapyrrole, the improvement consisting in the fact that these cells are treated with a compound which inhibits the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase in these cells, which brings about an accumulation of protoporphyrin IX in these cells. A process for the preparation of protoporphyrin IX is also disclosed and comprises the cultivation of eukaryotic microalgae in the presence of a protoporphyringen oxidase inhibitor.
申请公布号
DE3991484(C2)
申请公布日期
1995.02.23
申请号
DE19893991484
申请日期
1989.12.08
申请人
FMC CORP., PHILADELPHIA, PA., US
发明人
HALLING, BLAIK PHILIP, YARDLEY, PA., US;WITKOWSKI, DEBRA ANN, PARLIN, N.J., US