| 摘要 |
Anticoagulant compounds have been extensively used as rodenticides during the last 20 years. In most parts of the world rats have become resistant to anticoagulants. This circumstance seriously limits the usefulness of anticoagulant rodenticides, and gives rise to the need for a novel effective rodenticide. 6-Aminonicotinamide and 6-aminonicotinohydroxamic acid have been found to be potent rodent poisons, moreso in the rat than in the mouse. They are much less toxic to other species, such as the dog. An important feature of these compounds as rodenticides is the fact that nicotinamide is an excellent and complete antidote, even when administered after toxic symptoms have appeared. 6-Aminonicotinamide and 6-aminonicotinohydroxamic acid do not have objectionable taste or odor, and hence can be mixed with food products as edible carriers. These compounds are single-dose rodenticides in that the ingestion of only a few milligrams is fatal to a rodent, resulting in depth which occurs a few days after ingestion of the poison. Unlike the anticoagulant poisons, the mechanism of action of 6-aminonicotinamide and 6-aminonicotinohydroxamic acid is such that the development of resistance to them is virtually impossible.
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