USE OF MONOCLONAL ANTIBODIES FOR DETERMINING SENSITIVITY TO ACETYLIZABLE DRUGS

摘要

Monoclonal antibodies having specific binding affinities for 1-methylxanthine and 5-amino-6-acetylamino-1-methyluracil and hybridoma cell lines producing the monoclonal antibodies. Immunoassay methods for measuring amounts of 5-amino-6-acetylamino-1-methyluracil and 1-methylxanthine in biological samples are described. An immunoassay method for determining an acetylator phenotype of an individual includes determining a ratio of acetylated metabolite to nonacetylated metabolite in a biological sample from the individual having been administered an acetylizable drug. The invention also provides an immunoassay method for estimating a likely degree of sensitivity to an acetylizable therapeutic drug.