| 摘要 |
This invention provides C-22 substituted rapamycin derivatives of formulas (Ia) or (Ib) or a pharmaceutically acceptable salt thereof or a proline analogue thereof or a pharmaceutically acceptable salt of a proline analogue thereof which are useful for inducing immunosuppression and treating transplantation rejection, host vs. graft disease, autoimmune diseases, diseases of inflammation, solid tumors, fungal infections, adult T-cell leukemia/lymphomas and hyperproliferative vascular disorders.
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