发明名称 |
INACTIVATED RESPIRATORY SYNCYTIAL VIRAL VACCINES |
摘要 |
<p>An immunogenic composition capable of producing a respiratory syncytial (RS) virus specific immune response in a host immunized therewith comprises purified, inactivated RS virus which is substantially free from cellular and serum components and which is noninfectious, non-immunopotentiating, immunogenic and protective. The virus is grown on a vaccine quality cell line and harvested virus is purified under non-denaturing conditions to be substantially free from cellular and serum components. The purified RS virus is inactivated using .beta.-propiolactone, a non-ionic detergent, particularly n-octyl-.alpha.-D-glucopyranoside and n-octyl-.beta.-D-glucopyranoside, or ascorbic acid. The immunogenic composition may be formulated as a vaccine for in vivo administration to a human host. The immunogenic composition also may be used in diagnostic applications.</p> |
申请公布号 |
CA2167274(A1) |
申请公布日期 |
1995.02.16 |
申请号 |
CA19942167274 |
申请日期 |
1994.08.04 |
申请人 |
CONNAUGHT LABORATORIES LIMITED |
发明人 |
SANHUEZA, SONIA E.;EWASYSHYN, MARY E.;KLEIN, MICHEL H. |
分类号 |
A61K39/155;A61P31/12;C12N7/02;C12N7/04;C12N7/06;G01N33/569;(IPC1-7):C12N7/06 |
主分类号 |
A61K39/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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