发明名称 |
CHIMERIC RECEPTOR GENES AND CELLS TRANSFORMED THEREWITH. |
摘要 |
Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods. |
申请公布号 |
EP0638119(A1) |
申请公布日期 |
1995.02.15 |
申请号 |
EP19930908414 |
申请日期 |
1993.03.18 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
ESHHAR, ZELIG;SCHINDLER, DANIEL;WAKS, TOVA;GROSS, GIDEON |
分类号 |
C12N15/09;A61K31/70;A61K35/14;A61K35/18;A61K39/395;A61K47/48;A61K48/00;A61P35/00;C12N;C12N1/00;C12N5/00;C12N5/10;C12N15/12;C12N15/13;C12N15/62;C12R1/91;(IPC1-7):C12N1/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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