发明名称 |
Crystalline hydrates of cephalosporin and process for preparation thereof. |
摘要 |
<p>The present invention relates to a crystalline hydrate of 7-[(Z)-2-(2-aminothiazole-4-yl)-2-(2-carboxylprop-2-oxyimino) acetamido]-3-(5-methyl-1,4,6-triaminopyrimidinium-2-yl) thiomethyl-3-cephem-4-carboxylate and a composition comprising said compound as an active ingredient. Also provided herein is a process for preparation of the compound which comprises the steps of: dissolving the compound in an amorphous form or its salt in an acidic or basic solution; adjusting the pH of the solution to a range from 1.5 to 5.5 by adding a basic or acidic solution; precipitating the compound in a crystalline form in the solution; and recovering said crystalline hydrate of the compound. <IMAGE></p> |
申请公布号 |
EP0638573(A1) |
申请公布日期 |
1995.02.15 |
申请号 |
EP19930112822 |
申请日期 |
1993.08.10 |
申请人 |
LUCKY LTD. |
发明人 |
KIM, SUNG-HAG;KIM, JUN;YEO, JAE-HONG;OK, JONG-HOA;JO, NAG-SUG |
分类号 |
C07D501/00;C07D501/36;(IPC1-7):C07D501/36;C07D501/12 |
主分类号 |
C07D501/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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