Menetelmä 2-substituoitujen 3-kinoliinikarboksamidien valmistuksessa välituotteina käytettävien 2-asyyliamino- -oksobentseenipropaaniamidien valmistamiseksi

摘要

Novel alkyl beta -oxo-benzenepropanoates of the formula I wherein X is in the 5-,6-,7- or 8-position and is selected from the group consisting of hydrogen, halogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 4 carbon atoms, CF3-, CF3S- and CF3O-, R1' is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, R2' is selected from the group consisting of hydrogen, thiazolyl, 4,5-dihydrothiazolyl, pyridinyl, oxazolyl, isoxazolyl, imidazolyl, pyrimidyl, tetrazolyl, thienyl, benzothiazolyl and phenyl optionally substituted with at least one member of the group consisting of halogen, alkoxy of 1 to 4 carbon atoms, hydroxy, phenyl, CF3-, NO2- alkyl of 1 to 4 carbon atoms and alkyl of 1 to 4 carbon atoms substituted with amino, alkylamino or dialkylamino with alkyls of 1 to 3 carbon atoms or R1' and R2' taken together with the nitrogen atom to which they are attached form a member of the group consisting of thiazolyl, 4,5-dihydrothiazolyl, pyridinyl, oxazolyl, isoxazolyl, imidazolyl, pyrimidyl, tetrazolyl, thienyl and benzothiazolyl with the double bond being attached to the nitrogen atom, R is alkyl of 1 to 8 carbon atoms, R3 is selected from the group consisting of hydrogen, halogen and alkyl of 1 to 4 carbon atoms, R4 is hydrogen or halogen and R5 is halogen and a process for their preparation and a process for the preparation of compounds of the formula D wherein X, R1', R2', R3, R4 and R5 have the above definition.