发明名称 N-phenylpyri(mi)dine-N'-phenyl-urea derivatives, their preparation and their use as ACAT inhibitors.
摘要 <p>The present invention relates to a compound represented by the general formula (I): &lt;CHEM&gt; [wherein R&lt;1&gt; is a lower alkyl group, a lower cycloalkyl group, a lower alkoxy group, an aliphatic cyclic amino group which may be substituted by one or more lower alkyl groups, or a phenyl group which may be substituted by one or more halogen atoms, R&lt;2&gt; is a hydrogen atom or a lower alkyl group, R&lt;3&gt; and R&lt;4&gt;, which may be the same or different, are hydrogen atoms, halogen atoms, lower alkyl groups, lower haloalkyl groups, lower alkoxy groups or lower alkylthio groups, R&lt;5&gt;, R&lt;6&gt; and R&lt;7&gt;, which may be the same or different, are hydrogen atoms, halogen atoms, lower alkyl groups, lower haloalkyl groups, lower alkoxy groups, lower alkylthio groups or lower dialkylamino groups, and X is =N- or =CH-] or a pharmacologically acceptable salt thereof, which has inhibitory effect on acyl-CoA:cholesterol O-acyltransferase (ACAT), a process for producing said compound, and uses of said compound.</p>
申请公布号 EP0638557(A1) 申请公布日期 1995.02.15
申请号 EP19940111555 申请日期 1994.07.25
申请人 NIHON NOHYAKU CO., LTD. 发明人 NAGAMINE, MASASHI;YAMAMOTO, KENJI;HORIUCHI, KENJI;MATSUI, YOSHIMITSU;YOSHIDA, MASANORI
分类号 C07D213/75;C07D239/42;(IPC1-7):C07D239/42;C07D239/46;A61K31/44;A61K31/505;C07D239/48 主分类号 C07D213/75
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