发明名称 |
PIPERAZINE COMPOUNDS USED IN THERAPY |
摘要 |
Diarylmethyl piperazine compounds are disclosed having utility as exogenous receptor combinant species for binding with receptors such as delta, mu, sigma, and/or kappa receptors. Compounds of the invention may be employed as conjugates in agonist/antagonist pairs for transductional monitoring and assays of neurotransmitter function, and also variously exhibit therapeutic utility, including mediating analgesia, and possessing utility for the treatment of diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depression, asthma, emphysema, and apnea, cognitive disorders, and gastrointestinal disorders. |
申请公布号 |
WO9504051(A1) |
申请公布日期 |
1995.02.09 |
申请号 |
WO1994GB01641 |
申请日期 |
1994.07.29 |
申请人 |
THE WELLCOME FOUNDATION LIMITED;CHANG, KWEN-JEN;BISHOP, MICHAEL, JOSEPH;BUBACZ, DULCE, GARRIDO;MC NUTT, ROBERT, WALTON, JR. |
发明人 |
CHANG, KWEN-JEN;BISHOP, MICHAEL, JOSEPH;BUBACZ, DULCE, GARRIDO;MC NUTT, ROBERT, WALTON, JR. |
分类号 |
C07D295/14;A61K31/495;A61P1/00;A61P11/00;A61P13/02;A61P15/00;A61P25/00;A61P25/04;A61P25/24;A61P25/26;A61P25/30;A61P43/00;C07D213/75;C07D295/155 |
主分类号 |
C07D295/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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