| 摘要 |
<p>Plasminogen is purified by bringing a plasminogen-containing composition into contact with an anion exchanger and recovering the unadsorbed fraction. The contact is performed by adjusting the concentration of a salt such as sodium chloride to 0.1-2 w/v%, preferably to 0.4-0.8 w/v%, and, if desirable, adjusting the pH to 6 to 8. This method is useful to remove contaminants, in particular, a high-molecular substance having a plasminogen anti-genicity, from a plasminogen-containing composition. Further it permits plasminogen to be purified in a short time efficiently in a good yield at a low cost. Therefore this method is advantageous for preparing pure plasminogen from a large quantity of a plasminogen-containing composition and is extremely useful as a process for producing plasminogen on an industrial scale.</p> |
