| 摘要 |
<p>2-Benzoheterocyclyloxy or thiopropanolamine derivatives of formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein, Ro represents a moiety of formula (a), wherein one of X1 or X2 represents NH and the other of X1 or X2 represents NH, O or S and T represents hydrogen or one, two or three substituents selected from the list consisting of: hydroxy, amino, alkylamino, dialkylamino, alkylsulphonamido, arylsulphonamido, amidoformyl, halogen and alkoxy; X represents O or S; R?1 and R1a¿ each independently represents hydrogen or an alkyl group; R2 represents OCH¿2?CO2H, or an ester or amide thereof, or R?2¿ represents a moiety of formula (b), wherein R4 represents hydrogen, alkyl, hydroxyalkyl or cycloalkyl and R5 represents hydroxy, alkoxy, hydroxyalkyloxy or cycloalkyloxy or R5 represents hydrogen, alkyl, substituted alkyl, cycloalkyl or aryl or R5 together with OR4 represents O(CH¿2?)nO wherein n is 2, 3 or 4; and R?3¿ represents hydrogen, halogen, alkyl or alkoxy or R3 together with R2 represents a moiety of formula (c), or an ester or amide thereof; a process for the preparation of such a compound, a pharmaceutical composition comprising such a compound and the use of such a compound in medicine. The claimed compounds are adreno receptor agonists.</p> |
