| 摘要 |
<p>This invention relates to a novel synthesis of (R)-2-benzylsuccinic acid 4-(4-(N-t-butoxycarbonyl-methylamino)-piperidine) amide from racemic intermediates. The racemic (R)-2-benzylsuccinic acid 4-(4-(N-t-butoxycarbonyl-methylamino)-piperidine)amide is revolved through the formation of diasteromic salts with (S)-cyclohexylethylamine or (R)-cyclohexylethylamine. The pure diasteromic salt of formulae (IA, IB) can be found subsequently hydrolyzed with dilute acid to yield the pure enantiomer of (R)-2-benzylsuccinic acid 4-(4-(N-t-butoxycarbonyl-methylamino)piperidine)amide.</p> |
