| 摘要 |
Disclosed are oxazolidine derivatives of the formula (I) wherein Y is aziridino, azetidino, pyrrolidino, piperidino, 1-oxa-8-azaspiro[4.5]dec-8yl, hexahydroazepino or 4-R4-piperazino which is unsubstituted or substituted once by R2, OZ, SZ, N(Z)2 or -oxo; Z is in each case H, A, phenyl-CkH2k or Ac; R1 is phenyl which is substituted once by CN, H2N-CH2-, (A)2N-CH2-, H2N-C(=NH)-, H2N-C(=NH)-NH-, H2N-C(=NH)-NH-CH2-, HO-NH-C(=NH)- alebo HO-NH-C(=NH)-NH-, R2 je -CmH2m-COOR3 or -CnH2n-O-CpH2p-COOR3; R3 is H, A or benzyl; R4 is H, A, benzyl or -CmH2m-COOR3; A is in each case alkyl having 1 - 6 C atoms; Ac is carboxylic acyl having 1 - 11 C atoms; k and m are in each case independently 0, 1, 2 or 3; n is 0, 1 or 2; and p is 1, 2 or 3; or a salt thereof. Said derivatives inhibit the binding of fibrinogen to a fibrinogen receptor and are therefore usable in treating thrombosis, apoplexy, cardiac infarctus, inflammation or arteriosclerosis and tumors; process for the preparation of said derivatives and their use in preparing drugs; pharmaceutical compositions based on these derivatives.
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