| 摘要 |
PCT No. PCT/US91/09348 Sec. 371 Date Jun. 9, 1993 Sec. 102(e) Date Jun. 9, 1993 PCT Filed Dec. 13, 1991 PCT Pub. No. WO92/10277 PCT Pub. Date Jun. 25, 1992.This invention relates to the formation and use of a variable, multilayer system of discrete, discontinuous and nonsequential molecular sieves, comprising of agarose-acrylic gels of distinct composition. Each of the individual gel-layers of the system is designed according to partition and/or retardation coefficients for specific retention and therefore selective separation of selected molecules of different molecular sizes. The unique multilayer composite acrylic gel system of this invention makes it possible to separate micro- and macromolecules which differ in molecular weights by millions of daltons. So isolated any physically defined molecular groups are superiorly suitable for further chemical, physico-chemical or biological characterization.
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