Process for production of prostaglandins D2

摘要

The present invention provides a process for the production of PGD2, wherein 7-hydroxy prostaglandin F2 alpha is treated with thiocarbonyl diimidazole or its analog and subjecting thus treated product to the reaction to deoxidize the hydroxyl group at the 7-position, the reaction to convert the hydroxyl group to a protecting group, and the reaction to oxidize the hydroxyl group at the 11-position, thus giving PGD2 at a high efficiency.