| 发明名称 |
REGULATION OF TRANSCRIPTION FACTOR, NF-IL6/LAP |
| 摘要 |
.delta. An alteration in phosphorylation of serine 105, within the activation domain of NF-IL6/LAP, alters its transcription efficacy. Polypeptides, polynucleotides and methods of use for modified transcriptional activators allow regulation of gene expression. The figure shows CAT activity for HepG2 cells co-transfected with a CAT reporter plasmid and pCMV-LAP(wt), pCMV-LAP(Ala105), and pCMVLAP(Asp) plasmids.
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| 申请公布号 |
CA2167303(A1) |
申请公布日期 |
1995.02.02 |
| 申请号 |
CA19942167303 |
申请日期 |
1994.07.20 |
| 申请人 |
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发明人 |
KARIN, MICHAEL;TRAUTWEIN, CHRISTIAN |
| 分类号 |
G01N33/53;A61K31/00;A61K31/70;A61K38/00;A61K39/395;A61K48/00;A61P35/00;A61P37/00;A61P37/02;A61P43/00;C07H21/04;C07K14/47;C07K16/18;C12N5/10;C12N15/00;C12N15/02;C12N15/09;C12N15/12;C12P21/08;C12R1/91;G01N33/15;G01N33/50;(IPC1-7):C12N15/12;A61K38/17;C07K14/435;C12Q1/68 |
主分类号 |
G01N33/53 |
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