发明名称 |
POLYMERIC CARRIERS FOR NON-COVALENT DRUG CONJUGATION |
摘要 |
Polymeric carriers are polypeptides comprising at least one drug-binding domain that non-covalently binds a drug. A polymeric carrier may be attached to an antibody specific for desired target cells to form immunoconjugates that deliver a drug to the target cells in vivo. A polymeric carrier may be attached to a proteinaceous or a non-proteinaceous ligand or anti-ligand to form a conjugate useful in pretargeting protocols to deliver a drug to target cells in vivo. The carriers are derived from drug-binding proteins and produced through peptide synthesis or recombinant DNA technology.
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申请公布号 |
CA2167574(A1) |
申请公布日期 |
1995.02.02 |
申请号 |
CA19942167574 |
申请日期 |
1994.07.12 |
申请人 |
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发明人 |
GUSTAVSON, LINDA M.;ANDERSON, DAVID C.;MORGAN, ALTON C., JR. |
分类号 |
A61K38/00;A61K47/48;C07K14/36;C07K14/465;C07K14/47;C07K14/72;C07K14/76;(IPC1-7):A61K47/48;A61K47/42 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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