| 摘要 |
Antihypertensive imidazolyl(alkyl)-benzene derivs. of formuls (I) and pharmaceutically acceptable salts are prepd. In (I), R1= -4-COOH, -O- SO3H2, -SO3H, -C(CH3)2OH, -O-PO3H2, -NH2-PO3H2, -4-NHSO2Me, -4-NH- SO2CF3, etc.; R2= H, Cl, Br, I, F, NO2, C1-4 alkyl or alkoxy, COOH, aryl, furyl, etc.; R3- H, Cl, Br, I, F, C1-4 alkyl or alkoxy; R6= C2-10 alkyl, C3-10 alkenyl or alkynyl, C3-8 cycloalkyl, C4-10 cycloalkylalkyl, etc.; R7= H, F, Cl, Br, I, NO2, CF3 or CN; R8= H, CN, C1-10 alkyl or fluoroalkyl, C3-10 alkenyl or fluoroalkenyl, phenyl-(C2-6) alkenyl, etc.; r= 0-2. (I) are useful as angiotensin-II blcokers for treating hypertension and congestive heart failure.
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