| 摘要 |
A method and device for the automated non-destructive single inspection of solutions in transparent containers (52) for particle contamination, in injectable pharmaceutical solutions, with commercially viable acceptance percentages, while maintaining security within guidelines based on skilled human inspection. The containers are fully illuminated with forward scatter lighting (6') with total light flux for detection of low contrast particles, with the size of the particles being evaluated by the maximum instantaneous increase of detector current as the particle moves through the detection zone. Simultaneously therewith, narrow detection volumes are back lighted (6) with collimated light flux for detectionof high contrast or dark particles, within the detection volume, by light extinction with a decrease of detector current from the normal non-particle illumination. The maximum pulsatile current decrease is used to determine the size of the particle. Separate ilumination elements provide the forward scatter light (6') and the back lighting (6), and separate, non-overlapping detector areas capture the separate increase (FOD 2) and decrease (FOD 1, FOD 3) of detector current. Either separate detectors with separate lenses are utilized for detection of the increase and decrease of detector current or mirrors are utilized to reflect the respective images through a single lens onto separated sections of a single detector element.
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