(HETERO) 4-ARYLMETHOXY PHENYL DIAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, AND THEIR THERAPEUTICAL APPLICATIONS.

摘要

Title: "Derivatives of 4-(hereto)arylmethyloxy phenyl diazole, a method of preparing them and use thereof in therapy" (Inventors: Jean-Jacques KOENIG, Luc LEBRETON and Maryse MASSON) Applicant : DELALANDE S.A. (soci?t? anonmye) Derivatives having the formula: (I) in which R1 = C1-C4 alkyl and Ar is an aryl or heteroaryl group chosen from among the following: (i) where R2 represents a hydrogen atom one or two halogen atoms, a CN, NO2 or CF3 group, one, two or three C1-C4 alkyl or C1-C4 alkoxy groups or an amino group substituted by two C1-C4 alkyl groups, in which case the -W-V- chain represents -N = N- or and n = 2-6; (ii) pyridyl, in which case the -W-V- chain represents -N=N-and n = 1-6, 21 and acid addition salts of those derivatives (I) which are salt-forming. These derivatives are of use in therapy as agents for inhibiting type B monoamine oxydase.