发明名称 |
PARTIALLY MODIFIED AND RETRO-INVERTED TETRAPEPTIDES ANALOGUES OF C-REACTIVE PROTEIN FRAGMENTS. |
摘要 |
PCT No. PCT/EP93/00825 Sec. 371 Date Sep. 27, 1994 Sec. 102(e) Date Sep. 27, 1994 PCT Filed Apr. 2, 1993 PCT Pub. No. WO93/21208 PCT Pub. Date Oct. 28, 1993.Retro-inverted tetrapeptides of formula I e side-chain of threonine; R1 is the side-chain of arginine, leucine or glutamine; and R2 is a hydrogen atom or a metabolically perishable acyl group; with the proviso that when R1 is the side-chain of arginine, R cannot be the side-chain of threonine; diastereo-isomeric forms and pharmacologically acceptable salts, esters and amides thereof. These compounds are useful as immuno-stimulating agents. |
申请公布号 |
EP0636140(A1) |
申请公布日期 |
1995.02.01 |
申请号 |
EP19930908898 |
申请日期 |
1993.04.02 |
申请人 |
ITALFARMACO S.P.A. |
发明人 |
VERDINI, ANTONIO, SILVIO;PINORI, MASSIMO;CAPPELLETTI, SILVANA;GAZERRO, LAURA;LEONI, FLAVIO |
分类号 |
A61K38/00;A61P9/00;C07K5/02;C07K5/033 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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