Anti-herpes castanospermine esters

摘要

Certain Castanospermine ester derivatives of the formula: wherein R, R1 and R2 are each independently hydrogen, C1-14 alkanoyl, C1-14 alkenoyl, cyclohexanecarbonyl, C1-8 alkoxyacetyl, naphthalenecarbonyl optionally substituted by methyl or halogen; phenyl (C2-6 alkanoyl) wherein the phenyl is optionally substituted by methyl or halogen; cinnamoyl; pyridinecarbonyl optionally substituted by methyl or halogen; dihydropyridine carbonyl optionally substituted by C1-C10 alkyl; thiophenecarbonyl optionally substituted by methyl or halogen; or furancarbonyl optionally substituted by methyl or halogen; Y is hydrogen, C1-4 alkyl, C1-4 alkoxy, halogen, trifluoromethyl, C1-4alkylsulfonyl, C1-4 alkylmercapto, cyano or dimethylamino; Y' is hydrogen, C1-4 alkyl, C1-4 alkoxy, halogen or it is combined with Y to give 3,4-methylenedioxy; Y'' is hydrogen, C1-4 alkyl, C1-4 alkoxy or halogen; with R, R1 and R2 being selected in such a way that at least one of them, but not more than two of them, is hydrogen; are disclosed to be effective in treating diseases caused by Herpes Simplex Virus (HSV) Types 1 and 2.