发明名称 |
Synthesis of inhibitors of calmodulin-mediated enzymes including KS-501, KS-502 and their enantiomers |
摘要 |
The total synthesis of a group of compounds with inhibitory effects on calmodulin-mediated enzyme activities has been accomplished. Among these synthesized compounds are KS-501 and KS-502. Other compounds that have been synthesized by the described scheme are ent-KS-501 and ent-KS-502 which are enantiomers of KS-501 and KS-502 and which also have inhibitory effects on calmodulin-mediated enzyme activities.
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申请公布号 |
US5386019(A) |
申请公布日期 |
1995.01.31 |
申请号 |
US19920821719 |
申请日期 |
1992.01.15 |
申请人 |
YALE UNIVERSITY |
发明人 |
DANISHEFSKY, SAMUEL J.;DUSHIN, RUSSELL;HAIT, WILLIAM N. |
分类号 |
C07H15/203;(IPC1-7):C07H1/00;C07H13/02 |
主分类号 |
C07H15/203 |
代理机构 |
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代理人 |
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地址 |
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