| 摘要 |
Corticoid 17-alkyl carbonates of the formula I <IMAGE> with A = CHOH in any desired steric arrangement, C=O, CH2; Y = H, F, Cl; Z = H, F, CH3; R(1) = Hal, O-acyl, carbonylalkyl, sulphonic acid alkyl ester, sulphonic acid aryl ester; R(2) = branched alkyl or (CH2)2-4-OCH3 and R(3) = H, methyl, have an excellent local and topical antiinflammatory effect. They are distinguished by a particularly good ratio of local to systemic antiinflammatory activity and, in some cases, also show more potent local antiinflammatory activity than their isomeric corticoid 17-alkyl carbonates with a linear dialkyl group in the 17-alkyl carbonate moiety. <IMAGE> |
