| 摘要 |
PCT No. PCT/FR90/00234 Sec. 371 Date Dec. 28, 1990 Sec. 102(e) Date Dec. 28, 1990 PCT Filed Apr. 4, 1990 PCT Pub. No. WO90/12007 PCT Pub. Date Oct. 18, 1990.The invention relates to new sulphonamide derivatives of benzo-cyclic or benzo-heterocyclic acids and their derivatives of general formula I in or branched lower alkyl radical having 1 to 9 C; a phenyl radical which is unsubstituted or substituted by one or more groups: straight-chain or branched lower alkyl having 1 to 4 C, halogeno, alkoxy, nitro, amino, dialkylamino or CF3; a substituted or unsubstituted naphthalene; a thiophenyl radical; R1 represents a hydrogen or a straight-chain or branched lower alkyl or a benzyl; R2 represents a hydrogen, a straight-chain or branched lower alkyl group, a substituted or unsubstituted phenyl group or an aralkyl group; R3 represents a hydrogen or a straight-chain or branched lower alkyl (1 to 6 C); -X- represents a divalent functional radical chosen from the following: -CH2-; <IMAGE> <IMAGE> where R4=H or Me; A represents a benzo-cyclic or benzo-heterocyclic divalent radical chosen from the following (a) to (j): <IMAGE> (a) GE> (e) <IMAGE> (f) <IMAGE> (g) <IMAGE> (h) <IMAGE> (i) <IMAGE> (j) and n can assume the values 1 to 4 inclusive; and the therapeutically acceptable organic or inorganic salts (R3=H), the pure isomers or diastereoisomers or their mixture and all the pharmaceutical compositions of formula I with other active principles. The invention relates to the application of I as a medicament and the preparation processes.
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