发明名称 |
DERIVATES OF 19-NOR-VITAMINE D, PREPARATION PROCESS THEREFOR AND INTERMEDIARY COMPOUNDS THEREFOR |
摘要 |
<p>This invention provides a novel class of vitamin D-related compounds, namely the 1 alpha -hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided. The 19-nor analogs useful herein are of the general formula <IMAGE> where X1 and X2 each hydrogen, acyl, alkylisilyl or alkoxyalkyl, and where R is any of the typical side chains known for vitamin D type compounds.</p> |
申请公布号 |
RO109331(B1) |
申请公布日期 |
1995.01.30 |
申请号 |
RO19900146291 |
申请日期 |
1990.02.16 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION, MADISON |
发明人 |
ECTOR FLOID DELUCA;HEINRICH KONSTANTINE SCHNOES;KATO LEONARD PERLAM;RAFAL RYSZARD SICINSKI;JEAN MARTIN PRAHL |
分类号 |
A61K31/59;A61K;A61P5/12;A61P17/00;A61P35/00;A61P35/02;C07C;C07C401/00;C12N;G01N33/48;G01N33/574;(IPC1-7):C07C401/00 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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