发明名称 |
Pharmaceutical product for the treatment of sepsis |
摘要 |
An antibody to tumour necrosis factor- alpha (anti-TNF) and an antibody to bacterial lipopolysaccharide (anti-LPS) used together in a neutropenic rat model of sepsis are shown to enhance survival of the rats relative to either antibody used alone. Pharmaceutical products including each of the components are therefore of utility in therapy of sepsis. The anti-LPS antibody included may be specific for the O-specific chain of a particular bacterial lipopolysaccharide (serotype specific antibody) but preferably recognises the core glycolipid of lipopolysaccharide. |
申请公布号 |
AU7590694(A) |
申请公布日期 |
1995.01.27 |
申请号 |
AU19940075906 |
申请日期 |
1994.10.18 |
申请人 |
CELLTECH LIMITED;STEVEN MICHAEL OPAL;ALAN S. CROSS;JERALD C. SADOFF |
发明人 |
MARK WILLIAM BODMER;STEVEN MICHAEL OPAL;ALAN S. CROSS;JERALD C. SADOFF |
分类号 |
A61K31/16;A61K31/43;A61K31/495;A61K31/545;A61K31/65;A61K31/70;A61K39/395;A61K39/40;A61P31/04 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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