发明名称 |
Aus Phospholipiden bestehende Darreichungsform für wasserunlösliche Wirksubstanzen. |
摘要 |
Compositions comprising phospholipid-encapsulated vesicles of active ingredient and triglyceride are described. In a preferred embodiment the vesicles are composed of a hexamethylmelamine active ingredient, with trilaurin or trimyristin as the triglyceride and a mixture of distearoylphosphatidylcholine, distearoylphosphatidylglycerol and cholesterol in the phospholipid outer layer. Preferably the molar ratios of active ingredient: triglyceride : DSPC : CHOL : DSPG will be from about 1:4:2:1:0 to about 1:4:1:1:1. Glycerol may be added to the carrier phase to reduce agglomeration. The composition may be used to deliver otherwise aqueous-insoluble agents to humans or animals to treat, for example, tumors. |
申请公布号 |
DE3852409(D1) |
申请公布日期 |
1995.01.26 |
申请号 |
DE19883852409 |
申请日期 |
1988.01.22 |
申请人 |
VESTAR INC., SAN DIMAS, CALIF., US |
发明人 |
FORSSEN, ERIC ANTON, LA CANADA CALIFORNIA 91011, US |
分类号 |
A61K9/10;A61K9/107;A61K9/127;A61K9/133;A61K31/53;A61K47/24;A61P35/00;(IPC1-7):A61K9/50 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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