The present invention provides N<6>-benzyladenosine-5'-N-uronamide and related substituted compounds, particularly those containing substituents on the benzyl and/or uronamide groups, and modified xanthine ribosides, as well as pharmaceutical compositions containing such compounds. The present invention also provides a method of selectively activating an A3 adenosine receptor in a mammal, which method comprises acutely or chronically administering to a mammal in need of selective activation of its A3 adenosine receptor a therapeutically effective amount of a compound which binds with the A3 receptor so as to stimulate and A3 receptor-dependent response.
申请公布号
WO9502604(A1)
申请公布日期
1995.01.26
申请号
WO1994US07835
申请日期
1994.07.13
申请人
THE UNITED STATES OF AMERICA, REPRESENTED BY THE S
发明人
JACOBSON, KENNETH, A.;GALLO-RODRIGUEZ, CAROLA;VAN GALEN, PHILIP, J., M.;VON LUBITZ, DAG, K., J., E.;JEONG, HEAOK, KIM