Cyclic peptolides having the structure of a cyclosporin in which one amide linkage is replaced by an ester linkage are obtained by fermentation of fungal strains of the genus Cylindrotrichum Bonorden, or by cyclisation of a hydroxy-undecapeptide. The cyclic peptolides have immunosuppressive, anti-inflammatory and anti-parasitic properties.
申请公布号
DE3851268(T2)
申请公布日期
1995.01.26
申请号
DE19883851268T
申请日期
1988.06.15
申请人
SANDOZ-PATENT-GMBH, 79539 LOERRACH, DE
发明人
DREYFUSS, MICHAEL MORRIS, CH-4054 BASLE, CH;SCHREIER, MAX H., CH-4054 BASLE, CH;TSCHERTER, HANS, CH-4123 ALLSCHWIL, CH;WENGER, ROLAND, CH-4125 RIEHEN, CH;HASLBERGER, ALEXANDER, DR., A-1130 WIEN, AT
