Tris carbamic acid esters: inhibitors of cholesterol absorption; inhibitors of ACAT and CEH.

摘要

Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are therefore implicated in the inhibition of absorption of cholesterol and thus can lower serum cholesterol levels. Tris carbamic acid esters of the formula: where Z is or -Ar<1>-(CR=CR)1-3-Ar<2>, -Ar<1>-NR<7>-AR<2> and A is a linking group inhibit the enzymes CEH and/or ACAT (in vitro) and inhibit absorption of cholesterol.