发明名称 Benzospiroalkene derivatives, process for their preparation and pharmaceutical compostions containing them.
摘要 Compounds of formula (I): <IMAGE> in which: - X represents -CH2-, -(CH2)2-, -CH=CH-, -O-CH2-, S-CH2-, -SO-CH2- or -SO2-CH2-, - Y represents an oxygen or sulphur atom or a group -NR6-, - R1 represents a hydrogen atom or a linear or branched (C1-C6)alkyl group, - R2 represents a hydrogen or halogen atom, a linear or branched (C1-C6)alkyl group (substituted or unsubstituted), a hydroxyl group, a linear or branched (C1-C6)alkoxy group or a linear or branched (C1-C6)alkylthio group, - R3 represents a hydrogen or halogen atom, a linear or branched (C1-C6)alkyl group (substituted or unsubstituted), a hydroxyl group, a linear or branched (C1-C6)alkoxy group or a linear or branched (C1-C6)alkylthio group, - R4 represents a hydrogen atom (provided that, in this case, R1 represents a hydrogen atom), a halogen atom, a linear or branched (C1-C6)alkyl group (substituted or unsubstituted) or a hydroxyl group, or else - R1 and R2, R2 and R3, R3 and R4 or R4 and X form, together with the carbon atoms which carry them, a benzene ring, provided that, in the case where R1 and R2 form a benzene ring, X is other than -CH2- or -(CH2)2-, - R5 represents a hydrogen atom or an amino group (substituted or unsubstituted), - R6 has the same meaning as R1, their isomers and their addition salts with a pharmaceutically acceptable acid. Medicaments.
申请公布号 EP0635497(A2) 申请公布日期 1995.01.25
申请号 EP19940401549 申请日期 1994.07.06
申请人 ADIR ET COMPAGNIE 发明人 CORDI, ALEX;LACOSTE, JEAN-MICHEL;LAUBIE, MICHEL;VERBEUREN, TONY;DESCOMBES, JEAN-JACQUES
分类号 A61K31/415;A61K31/4162;A61K31/4184;A61K31/4188;A61K31/42;A61K31/423;A61K31/424;A61K31/425;A61K31/429;A61P25/02;A61P25/04;A61P25/06;A61P43/00;C07D235/02;C07D263/52;C07D491/10;C07D491/107;C07D495/10;C07D498/10;C07D513/10;(IPC1-7):C07D235/02 主分类号 A61K31/415
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