VERFAHREN ZUR HERSTELLUNG VON CEFTRIAXONDINATRIUM-SALZHEMIHEPTAHYDRAT

摘要

The invention relates to a process for preparing a disodium salt hemiheptahydrate of ceftriaxone of the formula I in which the disodium salt of 7-amino-3-{[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl)thio ]methyl}-3-cephem-4-carboxylic acid is reacted with a reactive 2-(2-aminothiazol-4-yl)-2-syn-methoxyiminoacetic acid derivative such as 2-benzothiazolyl thioester in an aqueous solution and in the presence of a suitable inert organic solvent such as acetone at a temperature between 0 DEG C and 40 DEG C, in particular at room temperature, and subsequently the required compound is isolated in a very pure form and in a high total yield. Ceftriaxone is a cephalosporin antibiotic of the third generation for parenteral use and is a valuable agent for the treatment of serious infections.