发明名称 |
Process for the deoxygenation of nucleosides |
摘要 |
An efficient process for the deoxygenation of 2'- and or 3'-hydroxyl groups of a nucleoside that includes reacting the hydroxyl group with 3-halopropionitrile or 2-nitroethylhalide and carbon disulfide in base to form a 2'- or 3'-(cyanoethylthio or nitroethylthio)thiocarbonyl, that is reductively eliminated and replaced with hydrogen. The deoxygenation process can be used in a wide variety of nucleoside syntheses that require the elimination of the 2'- or 3'-hydroxyl groups, including the preparation of 3'-substituted-2',3'-dideoxynucleosides such as 3'-azido-3'-deoxythymidine and 3'-azido-2',3'-dideoxyuridine.
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申请公布号 |
US5384396(A) |
申请公布日期 |
1995.01.24 |
申请号 |
US19910665751 |
申请日期 |
1991.03.07 |
申请人 |
THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. |
发明人 |
CHU, CHUNG K.;CHEN, YAOQUAN |
分类号 |
C07H19/04;(IPC1-7):C07H19/00 |
主分类号 |
C07H19/04 |
代理机构 |
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代理人 |
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地址 |
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