Stable quinolone and napthyridine premix formulations

摘要

Pharmaceutical compositions suitable for parenteral administration to human or veterinary patients, which comprise (a) a quinolone antimicrobial agent in aqueous solution in a concentration of between about 100 and about 300 mg/ml; (b) a first water-miscible cosolvent (preferably ethanol) in a concentration of between about 10 % and about 15 % by volume; (c) an optional second water-miscible cosolvent (preferably proplylene glycol) in a concentration of between about 25 % and about 40 % by volume; and (d) a pH-adjusting agent in a concentration sufficient to result in a composition pH of between about 9.5 and about 11.5.