发明名称 Acyclic amidine group-containing diphosphonic acid derivatives for pharmaceutical compositions and preparation thereof
摘要 PCT No. PCT/EP93/01833 Sec. 371 Date Mar. 28, 1995 Sec. 102(e) Date Mar. 28, 1995 PCT Filed Jul. 13, 1993 PCT Pub. No. WO94/02492 PCT Pub. Date Feb. 3, 1994Compounds of the formula I <IMAGE> (I) in which R1 signifies hydrogen, a straight-chained, branched, saturated or unsaturated alkyl radical with 1-9 carbon atoms possibly substituted by phenyl or a phenyl ring which is possibly substituted by C1-C3alkyl, C1-C3-alkoxy or halogen, R2 signifies hydrogen or C1-C3-alkyl, whereby the two radicals can be the same or different, R represents hydrogen or a straight-chained or branched alkyl radical with 1-4 carbon atoms, X signifies an alkylene chain with 1-6 carbon atoms which can be substituted one or more times by C1-C3-alkyl and can possibly be interrupted by oxygen, whereby 1 or 2 carbon stems of the alkylene chain can possibly be part of a cyclopentyl or cyclohexyl ring and Y signifies hydrogen, hydroxyl or amino group possibly substituted by alkyl groups with 1-6 carbon atoms, as well as their pharmacologically acceptable salts, processes for their preparation, as well as medicaments for the treatment of calcium metabolism disturbances.
申请公布号 ZA9305224(B) 申请公布日期 1995.01.20
申请号 ZA19930005224 申请日期 1993.07.20
申请人 BOEHRINGER MANNHEIM GMBH. 发明人 HARALD ZILCH;FRIEDER BAUSS
分类号 A61K31/685;A61K31/66;A61P3/00;A61P3/14;C07F9/38;C07F9/40 主分类号 A61K31/685
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