| 发明名称 |
SALMONELLA VACCINES |
| 摘要 |
A bacterial cell the virulence of which is attenuated by a first mutation in a PhoP regulon and a second mutation in an aromatic amino acid synthetic gene and bacterial cells the virulence of which is attenuated by a mutation in one or more PhoP-activated genes or one or more PhoP-repressed genes.
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| 申请公布号 |
CA2166787(A1) |
申请公布日期 |
1995.01.19 |
| 申请号 |
CA19942166787 |
申请日期 |
1994.07.07 |
| 申请人 |
THE GENERAL HOSPITAL CORPORATION;PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
MEKALANOS, JOHN J.;MILLER, SAMUEL I., III |
| 分类号 |
A61K39/00;A61K39/02;A61K39/112;A61P31/04;C07K14/255;C12N1/21;C12N15/01;C12N15/09;C12N15/74;C12Q1/68;C12R1/01;C12R1/42;(IPC1-7):C12N1/36;A61K35/74 |
主分类号 |
A61K39/00 |
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