摘要 |
This invention provides mammalian Flt3 ligands and variants thereof, nucleic acids encoding the same, recombinant vectors and host cells comprising such nucleic acids, and antibodies or binding fragments thereof which specifically bind to the ligands or variants thereof, kits, and pharmaceutical compositions for modifying the biological activity of cells bearing Flt3 ligand receptors. Methods for making and using the foregoing materials are also provided by this invention. More particularly, a variant of the invention has Ala at alpha alpha 72. |
申请人 |
SCHERING CORPORATION;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE M;HANNUM, CHARLES, H.;LEE, FRANK, D.;BIRNBAUM, DANIEL;CULPEPPER, JANICE, A. |
发明人 |
HANNUM, CHARLES, H.;LEE, FRANK, D.;BIRNBAUM, DANIEL;CULPEPPER, JANICE, A. |