发明名称 |
ASSAY FOR YKL-40 AS A MARKER FOR DEGRADATION OF MAMMALIAN CONNECTIVE TISSUE MATRICES |
摘要 |
The invention is a method of identifying the presence of, and monitoring, a disease state in a mammal which is associated with degradation of connective tissue in the mammal. The method detects and determines whether diagnostically or prognostically significant levels of YKL-40 protein and/or YKL-40 peptide are present in a biological sample. The method can be used, for example, to identify the presence of inflammatory or degenerative joint desease or degeneration of connective tissue in organs. Serum YKL-40 levels as detected and quantified by the inventive method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers. The figure shows the elution position of substantially pure serum YKL-40 on a gel filtration column.
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申请公布号 |
WO9501995(A1) |
申请公布日期 |
1995.01.19 |
申请号 |
WO1994US07754 |
申请日期 |
1994.07.08 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;PRICE, PAUL, A.;JOHANSEN, JULIA, S. |
发明人 |
PRICE, PAUL, A.;JOHANSEN, JULIA, S. |
分类号 |
G01N33/53;A61K38/00;A61K39/395;A61P29/00;A61P43/00;C07K14/47;C07K16/18;G01N33/564;G01N33/574;G01N33/577;G01N33/68;(IPC1-7):C07K15/00;C12Q1/00;C12Q1/25;G01N33/531;G01N33/573;G01N33/60;A61K35/14;A61K37/02;A01N37/18 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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