发明名称 |
NOVEL PROCESS FOR -i(TRANS)-6- 2-(SUBSTITUTED-PYRROL-1-YL)ALKYL]PYRAN-2-ONE INHIBITORS OF CHOLESTEROL SYNTHESIS |
摘要 |
<p>An improved process for the preparation of trans-6-(2-(substituted-pyrrole-1-yl)alkyl)pyran-2-ones by a novel synthesis is described where (alpha)-metalated N,N-disubstituted acetamide is converted in seven operations to the desired products, and specifically, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1H-pyrrole-3-carboxamide, as well as other valuable intermediates used in the processes and prodrugs which are bioconverted to hypolipidemic and hypocholesterolemic agents and pharmaceutical compositions of the same.</p> |
申请公布号 |
GR3024784(T3) |
申请公布日期 |
1998.01.30 |
申请号 |
GR19970402408T |
申请日期 |
1997.09.17 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
BUTLER, DONALD, EUGENE;LE, TUNG, VAN;NANNINGA, THOMAS, NORMAN |
分类号 |
C07D295/18;A61K31/40;A61K31/4025;A61K31/4427;A61K31/443;A61K31/445;A61P3/06;C07C255/20;C07C255/26;C07C255/27;C07D207/06;C07D207/325;C07D207/34;C07D211/10;C07D211/16;C07D265/30;C07D319/04;C07D319/06;C07D401/06;C07D405/02;C07D405/06;C07D405/14;C07D491/113;(IPC1-7):C07D405/06;C07C255/13 |
主分类号 |
C07D295/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|