发明名称 |
Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells |
摘要 |
PCT No. PCT/FR90/00532 Sec. 371 Date Apr. 25, 1991 Sec. 102(e) Date Apr. 25, 1991 PCT Filed Jul. 13, 1990 PCT Pub. No. WO91/00909 PCT Pub. Date Jan. 24, 1991.The invention concerns a new urate oxidase activity protein which has the following sequence: - Ser Ala Val Lys Ala Ala Arg Tyr Gly -Lys Asp Asn Val Arg Val Tyr Lys Val His -Lys Asp Glu Lys Thr Gly Val Gln Thr Val -Tyr Glu Met Thr Val Cys Val Leu Leu Glu -Gly Glu Ile Glu Thr Ser Tyr Thr Lys Ala -Asp Asn Ser Val Ile Val Ala Thr Asp Ser -Ile Lys Asn Thr Ile Tyr Ile Thr Ala Lys -Gln Asn Pro Val Thr Pro Pro Glu Leu Phe -Gly Ser Ile Leu Gly Thr His Phe Ile Glu -Lys Tyr Asn His Ile His Ala Ala His Val -Asn Ile Val Cys His Arg Trp Thr Arg Met -Asp Ile Asp Gly Lys Pro His Pro His Ser -Phe Ile Arg Asp Ser Glu Glu Lys Arg Asn -Val Gln Val Asp Val Val Glu Gly Lys Gly -Ile Asp Ile Lys Ser Ser Leu Ser Gly Leu -Thr Val Leu Lys Ser Thr Asn Ser Gln Phe -Trp Gly Phe Leu Arg Asp Glu Tyr Thr Thr -Leu Lys Glu Thr Trp Asp Arg Ile Leu Ser -Thr Asp Val Asp Ala Thr Trp Gln Trp Lys -Asn Phe Ser Gly Leu Gln Glu Val Arg Ser -His Val Pro Lys Phe Asp Ala Thr Trp Ala -Thr Ala Arg Glu Val Thr Leu Lys Thr Phe -Ala Glu Asp Asn Ser Ala Ser Val Gln Ala -Thr Met Tyr Lys Met Ala Glu Gln Ile Leu -Ala Arg Gln Gln Leu Ile Glu Thr Val Glu -Tyr Ser Leu Pro Asn Lys His Tyr Phe Glu -Ile Asp Leu Ser Trp His Lys Gly Leu Gln -Asn Thr Gly Lys Asn Ala Glu Val Phe Ala -Pro Gln Ser Asp Pro Asn Gly Leu Ile Lys -Cys Thr Val Gly Arg Ser Ser Leu Lys Ser -Lys Leu - optionally preceeded by a methionine, or in that it may present a degree of substantial homology with this sequence. The invention is also aimed at medicines containing this protein as well as the genetic engineering implements to obtain it.
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申请公布号 |
US5382518(A) |
申请公布日期 |
1995.01.17 |
申请号 |
US19920920519 |
申请日期 |
1992.07.28 |
申请人 |
SANOFI |
发明人 |
CAPUT, DANIEL;FERRARA, PASCUAL;GUILLEMOT, JEAN-CLAUDE;KAGHAD, MOURAD;LEGOUX, RICHARD;LOISON, GERARD;LARBRE, ELISABETH;LUPKER, JOHANNES;LEPLATOIS, PASCAL;SALOME, MARC;LAURENT, PATRICK |
分类号 |
C12N9/06;C12N15/53;(IPC1-7):C12N9/00;C12P21/00 |
主分类号 |
C12N9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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